Drug interactions
Cannabidiol + Paclitaxel
Severity: Moderate
Cannabidiol and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can inhibit CYP2C8, a major pathway for paclitaxel clearance, and may raise paclitaxel exposure. This could increase neutropenia and peripheral neuropathy, though clinical data are limited.
What this interaction means in plain words
Cannabidiol and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Paclitaxel belongs to Oncology.
Why it happens
Cannabidiol inhibits CYP2C8-mediated paclitaxel metabolism.
What to do
Monitor blood counts and neuropathy symptoms when cannabidiol is used with paclitaxel. Consider paclitaxel dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Paclitaxel?
MediHelp rates the interaction as moderate. Cannabidiol and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can inhibit CYP2C8, a major pathway for paclitaxel clearance, and may raise paclitaxel exposure. This could increase neutropenia and peripheral neuropathy, though clinical data are limited.
How serious is the interaction between Cannabidiol and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms when cannabidiol is used with paclitaxel. Consider paclitaxel dose reduction if toxicity emerges.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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