Drug interactions
Cannabidiol + Ramelteon
Severity: Moderate
Cannabidiol and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can inhibit and possibly induce CYP1A2, the main enzyme metabolizing ramelteon. Ramelteon exposure may therefore change, along with its effects, and additive drowsiness is also possible.
What this interaction means in plain words
Cannabidiol and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Cannabidiol modulates CYP1A2 activity, altering ramelteon clearance.
What to do
Monitor response and sedation when cannabidiol is started or stopped. Adjust the ramelteon dose if effects are excessive or reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Ramelteon?
MediHelp rates the interaction as moderate. Cannabidiol and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can inhibit and possibly induce CYP1A2, the main enzyme metabolizing ramelteon. Ramelteon exposure may therefore change, along with its effects, and additive drowsiness is also possible.
How serious is the interaction between Cannabidiol and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response and sedation when cannabidiol is started or stopped. Adjust the ramelteon dose if effects are excessive or reduced.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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