Drug interactions
Cannabidiol + Sertraline
Severity: Moderate
Cannabidiol and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19 and can increase sertraline concentrations, adding to its adverse effects. Sertraline's weak CYP3A4 inhibition has little effect on cannabidiol. Both agents can cause somnolence and sedation.
What this interaction means in plain words
Cannabidiol and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Cannabidiol inhibits CYP2C19, reducing sertraline clearance, and additive CNS depression may occur.
What to do
Monitor for sertraline adverse effects such as nausea, sedation and serotonergic symptoms, and reduce the sertraline dose if they occur. Warn the patient about additive drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Sertraline?
MediHelp rates the interaction as moderate. Cannabidiol and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19 and can increase sertraline concentrations, adding to its adverse effects. Sertraline's weak CYP3A4 inhibition has little effect on cannabidiol. Both agents can cause somnolence and sedation.
How serious is the interaction between Cannabidiol and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sertraline adverse effects such as nausea, sedation and serotonergic symptoms, and reduce the sertraline dose if they occur. Warn the patient about additive drowsiness.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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