Drug interactions
Cannabidiol + Tranylcypromine
Severity: Moderate
Cannabidiol and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine inhibits CYP2C19 to a modest degree and may raise cannabidiol levels, increasing sedation, somnolence and possibly liver enzyme elevations. The effect is generally manageable.
What this interaction means in plain words
Cannabidiol and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19-mediated cannabidiol metabolism by tranylcypromine.
What to do
Monitor for sedation and adverse effects, and consider lowering the cannabidiol dose. Check liver enzymes if clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Tranylcypromine?
MediHelp rates the interaction as moderate. Cannabidiol and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranylcypromine inhibits CYP2C19 to a modest degree and may raise cannabidiol levels, increasing sedation, somnolence and possibly liver enzyme elevations. The effect is generally manageable.
How serious is the interaction between Cannabidiol and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and adverse effects, and consider lowering the cannabidiol dose. Check liver enzymes if clinically indicated.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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