Drug interactions
Cannabidiol + Verapamil
Severity: Moderate
Cannabidiol and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may raise cannabidiol concentrations through CYP3A4 inhibition. Increased exposure may cause more sedation, somnolence, diarrhea and elevated liver enzymes.
What this interaction means in plain words
Cannabidiol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 reduces cannabidiol metabolism.
What to do
Monitor for sedation and adverse effects and consider reducing the cannabidiol dose. Check liver enzymes if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Verapamil?
MediHelp rates the interaction as moderate. Cannabidiol and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may raise cannabidiol concentrations through CYP3A4 inhibition. Increased exposure may cause more sedation, somnolence, diarrhea and elevated liver enzymes.
How serious is the interaction between Cannabidiol and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and adverse effects and consider reducing the cannabidiol dose. Check liver enzymes if symptoms develop.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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