Drug interactions
Capecitabine + Dexlansoprazole
Severity: Moderate
Capecitabine and Dexlansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Observational data suggest that PPIs may be associated with poorer outcomes in patients taking capecitabine, possibly through reduced absorption. The evidence is inconsistent and not confirmed by pharmacokinetic studies.
What this interaction means in plain words
Capecitabine and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Higher gastric pH may impair tablet dissolution and absorption; the mechanism is not firmly established.
What to do
Review whether the PPI is still needed and consider an H2 blocker or deprescribing; if continued, monitor oncologic response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Dexlansoprazole?
MediHelp rates the interaction as moderate. Capecitabine and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Observational data suggest that PPIs may be associated with poorer outcomes in patients taking capecitabine, possibly through reduced absorption. The evidence is inconsistent and not confirmed by pharmacokinetic studies.
How serious is the interaction between Capecitabine and Dexlansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether the PPI is still needed and consider an H2 blocker or deprescribing; if continued, monitor oncologic response.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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