Drug interactions
Capecitabine + Glyburide
Severity: Moderate
Capecitabine and Glyburide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine, through fluorouracil, may inhibit CYP2C9, as seen with warfarin. This could raise glyburide exposure and increase hypoglycemia risk. Evidence for sulfonylureas is limited.
What this interaction means in plain words
Capecitabine and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Glyburide belongs to Endocrine.
Why it happens
Possible inhibition of CYP2C9-mediated glyburide metabolism by capecitabine.
What to do
Monitor blood glucose during capecitabine therapy and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Glyburide?
MediHelp rates the interaction as moderate. Capecitabine and Glyburide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capecitabine, through fluorouracil, may inhibit CYP2C9, as seen with warfarin. This could raise glyburide exposure and increase hypoglycemia risk. Evidence for sulfonylureas is limited.
How serious is the interaction between Capecitabine and Glyburide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during capecitabine therapy and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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