Drug interactions
Capecitabine + Histrelin
Severity: Moderate
Capecitabine and Histrelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Histrelin, a GnRH agonist, causes androgen deprivation that can lengthen the QT interval. Capecitabine has also been linked to QT prolongation, so the combination may modestly increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Capecitabine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Histrelin belongs to Musculoskeletal.
Why it happens
Additive effects on cardiac repolarization; androgen deprivation from GnRH agonists plus fluoropyrimidine-associated QT effects.
What to do
Check baseline ECG and electrolytes and repeat them during treatment in patients with cardiac risk factors. Avoid adding other QT-prolonging drugs where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Other interactions of Histrelin
- Amiodarone + Histrelin Major
- Anagrelide + Histrelin Major
- Histrelin + Thioridazine Major
- Alfuzosin + Histrelin Moderate
- Amisulpride + Histrelin Moderate
- Asenapine + Histrelin Moderate
Frequently asked questions
Can I take Capecitabine with Histrelin?
MediHelp rates the interaction as moderate. Capecitabine and Histrelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Histrelin, a GnRH agonist, causes androgen deprivation that can lengthen the QT interval. Capecitabine has also been linked to QT prolongation, so the combination may modestly increase arrhythmia risk in susceptible patients.
How serious is the interaction between Capecitabine and Histrelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and repeat them during treatment in patients with cardiac risk factors. Avoid adding other QT-prolonging drugs where possible.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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