Drug interactions
Capivasertib + Cyclosporin
Severity: Moderate
Capivasertib and Cyclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase capivasertib exposure through CYP3A4 inhibition. Higher exposure may increase toxicities such as hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Capivasertib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated capivasertib metabolism by cyclosporine.
What to do
Reduce the capivasertib dose as recommended in labeling when given with a moderate CYP3A4 inhibitor, and monitor blood glucose and skin and GI toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Cyclosporin?
MediHelp rates the interaction as moderate. Capivasertib and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase capivasertib exposure through CYP3A4 inhibition. Higher exposure may increase toxicities such as hyperglycemia, diarrhea and rash.
How serious is the interaction between Capivasertib and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the capivasertib dose as recommended in labeling when given with a moderate CYP3A4 inhibitor, and monitor blood glucose and skin and GI toxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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