Drug interactions
Capivasertib + Enzalutamide
Severity: Major
Capivasertib and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide, a strong CYP3A inducer, is expected to lower capivasertib exposure. This may reduce its anticancer efficacy.
What this interaction means in plain words
Capivasertib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capivasertib belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
CYP3A4 induction by enzalutamide increases capivasertib metabolic clearance.
What to do
Avoid coadministration and choose an alternative to enzalutamide if possible. Monitor disease response closely if both must be used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Enzalutamide?
MediHelp rates the interaction as major. Capivasertib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide, a strong CYP3A inducer, is expected to lower capivasertib exposure. This may reduce its anticancer efficacy.
How serious is the interaction between Capivasertib and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration and choose an alternative to enzalutamide if possible. Monitor disease response closely if both must be used.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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