Drug interactions
Capivasertib + Erythromycin
Severity: Moderate
Capivasertib and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capivasertib is metabolized mainly by CYP3A4, and erythromycin as a moderate inhibitor may increase capivasertib exposure. This can worsen hyperglycemia, diarrhea and rash.
What this interaction means in plain words
Capivasertib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capivasertib belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of capivasertib.
What to do
Reduce the capivasertib dose per labeling when given with a moderate CYP3A inhibitor. Monitor blood glucose and skin and gastrointestinal toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Capivasertib
Frequently asked questions
Can I take Capivasertib with Erythromycin?
MediHelp rates the interaction as moderate. Capivasertib and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capivasertib is metabolized mainly by CYP3A4, and erythromycin as a moderate inhibitor may increase capivasertib exposure. This can worsen hyperglycemia, diarrhea and rash.
How serious is the interaction between Capivasertib and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the capivasertib dose per labeling when given with a moderate CYP3A inhibitor. Monitor blood glucose and skin and gastrointestinal toxicity.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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