Drug interactions
Capmatinib + Efavirenz
Severity: Major
Capmatinib and Efavirenz: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz may markedly decrease capmatinib concentrations by inducing CYP3A4, which could compromise treatment of MET-altered lung cancer.
What this interaction means in plain words
Capmatinib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capmatinib belongs to Oncology; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, accelerating capmatinib metabolism.
What to do
Avoid the combination and use an antiretroviral without inducing properties. Monitor tumor response if no alternative exists.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Capmatinib
Frequently asked questions
Can I take Capmatinib with Efavirenz?
MediHelp rates the interaction as major. Capmatinib and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz may markedly decrease capmatinib concentrations by inducing CYP3A4, which could compromise treatment of MET-altered lung cancer.
How serious is the interaction between Capmatinib and Efavirenz?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antiretroviral without inducing properties. Monitor tumor response if no alternative exists.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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