Drug interactions
Amobarbital + Capmatinib
Severity: Major
Amobarbital and Capmatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital induces CYP3A4, which contributes to capmatinib metabolism. Lower capmatinib concentrations may reduce antitumor effect.
What this interaction means in plain words
Amobarbital and Capmatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Capmatinib belongs to Oncology.
Why it happens
CYP3A4 induction by amobarbital increases capmatinib clearance.
What to do
Avoid strong CYP3A inducers with capmatinib and choose an alternative to amobarbital. Monitor tumor response if co-use is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Capmatinib
- Apalutamide + Capmatinib Major
- Capmatinib + Carbamazepine Major
- Capmatinib + Efavirenz Major
- Capmatinib + Enzalutamide Major
- Capmatinib + Phenytoin Major
- Capmatinib + Secobarbital Major
Frequently asked questions
Can I take Amobarbital with Capmatinib?
MediHelp rates the interaction as major. Amobarbital and Capmatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital induces CYP3A4, which contributes to capmatinib metabolism. Lower capmatinib concentrations may reduce antitumor effect.
How serious is the interaction between Amobarbital and Capmatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A inducers with capmatinib and choose an alternative to amobarbital. Monitor tumor response if co-use is unavoidable.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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