Drug interactions
Capmatinib + Enzalutamide
Severity: Major
Capmatinib and Enzalutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A inducers reduce capmatinib exposure, which may impair efficacy in MET-driven lung cancer. Enzalutamide is expected to have this effect.
What this interaction means in plain words
Capmatinib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Capmatinib belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, increasing the metabolism of capmatinib.
What to do
Avoid concurrent use; capmatinib labeling advises against strong CYP3A inducers. Select an alternative therapy for prostate cancer if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Capmatinib
- Amobarbital + Capmatinib Major
- Apalutamide + Capmatinib Major
- Capmatinib + Carbamazepine Major
- Capmatinib + Efavirenz Major
- Capmatinib + Phenytoin Major
- Capmatinib + Secobarbital Major
Frequently asked questions
Can I take Capmatinib with Enzalutamide?
MediHelp rates the interaction as major. Capmatinib and Enzalutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A inducers reduce capmatinib exposure, which may impair efficacy in MET-driven lung cancer. Enzalutamide is expected to have this effect.
How serious is the interaction between Capmatinib and Enzalutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; capmatinib labeling advises against strong CYP3A inducers. Select an alternative therapy for prostate cancer if feasible.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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