Drug interactions
Capreomycin + Cisplatin
Severity: Major
Capreomycin and Cisplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic and ototoxic, and capreomycin can also cause electrolyte wasting. Combined use increases the risk of acute kidney injury, hearing loss and vestibular damage.
What this interaction means in plain words
Capreomycin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity and ototoxicity via renal tubular and cochlear injury.
What to do
Avoid the combination where alternatives exist. If unavoidable, monitor serum creatinine, magnesium, potassium and hearing with audiometry.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisplatin
- Cidofovir + Cisplatin Contraindicated
- Adefovir + Cisplatin Major
- Adenovirus types 4 and 7 live + Cisplatin Major
- Amikacin + Cisplatin Major
- Amphotericin b deoxycholate + Cisplatin Major
- Amphotericin b + Cisplatin Major
Frequently asked questions
Can I take Capreomycin with Cisplatin?
MediHelp rates the interaction as major. Capreomycin and Cisplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic and ototoxic, and capreomycin can also cause electrolyte wasting. Combined use increases the risk of acute kidney injury, hearing loss and vestibular damage.
How serious is the interaction between Capreomycin and Cisplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where alternatives exist. If unavoidable, monitor serum creatinine, magnesium, potassium and hearing with audiometry.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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