Drug interactions
Capreomycin + Gentamicin
Severity: Major
Capreomycin and Gentamicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic and ototoxic, and capreomycin has additional neuromuscular blocking activity. Combined use raises the risk of kidney injury, hearing and vestibular damage, and neuromuscular weakness.
What this interaction means in plain words
Capreomycin and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity, ototoxicity and neuromuscular blockade from two agents with overlapping toxicities.
What to do
Avoid combining where alternatives exist; if unavoidable, monitor renal function, electrolytes, audiometry and gentamicin levels closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Capreomycin with Gentamicin?
MediHelp rates the interaction as major. Capreomycin and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic and ototoxic, and capreomycin has additional neuromuscular blocking activity. Combined use raises the risk of kidney injury, hearing and vestibular damage, and neuromuscular weakness.
How serious is the interaction between Capreomycin and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where alternatives exist; if unavoidable, monitor renal function, electrolytes, audiometry and gentamicin levels closely.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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