Drug interactions
Captopril + Clomipramine
Severity: Moderate
Captopril and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine can cause orthostatic hypotension through alpha-adrenergic blockade, and this adds to the blood pressure lowering of captopril. Dizziness, falls and syncope may occur, particularly in older patients or at treatment initiation.
What this interaction means in plain words
Captopril and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Clomipramine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects from ACE inhibition and tricyclic alpha-1 adrenergic blockade.
What to do
Monitor blood pressure and orthostatic symptoms when starting or changing doses. Reduce the dose of one agent if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Captopril with Clomipramine?
MediHelp rates the interaction as moderate. Captopril and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine can cause orthostatic hypotension through alpha-adrenergic blockade, and this adds to the blood pressure lowering of captopril. Dizziness, falls and syncope may occur, particularly in older patients or at treatment initiation.
How serious is the interaction between Captopril and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or changing doses. Reduce the dose of one agent if symptomatic hypotension develops.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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