Drug interactions
Captopril + Dalteparin
Severity: Moderate
Captopril and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress adrenal aldosterone production, and an ACE inhibitor also reduces aldosterone, so serum potassium may rise. The risk is higher with renal impairment, diabetes or other potassium-raising drugs.
What this interaction means in plain words
Captopril and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Additive suppression of aldosterone leading to reduced renal potassium excretion.
What to do
Check serum potassium and renal function at baseline and periodically during prolonged co-therapy. Treat hyperkalemia if it develops and review other potassium-raising drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Captopril with Dalteparin?
MediHelp rates the interaction as moderate. Captopril and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress adrenal aldosterone production, and an ACE inhibitor also reduces aldosterone, so serum potassium may rise. The risk is higher with renal impairment, diabetes or other potassium-raising drugs.
How serious is the interaction between Captopril and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function at baseline and periodically during prolonged co-therapy. Treat hyperkalemia if it develops and review other potassium-raising drugs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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