Drug interactions
Captopril + Desflurane
Severity: Moderate
Captopril and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane cause vasodilation and myocardial depression, and ACE inhibitors blunt compensatory angiotensin II vasoconstriction. Together they can produce pronounced hypotension during induction and maintenance of anesthesia.
What this interaction means in plain words
Captopril and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Desflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic hypotensive effects, with ACE inhibition reducing the renin-angiotensin compensation for anesthetic-induced vasodilation.
What to do
Monitor blood pressure closely during anesthesia and treat hypotension with fluids or vasopressors. Consider whether to withhold the ACE inhibitor on the morning of surgery according to local perioperative protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Desflurane
Frequently asked questions
Can I take Captopril with Desflurane?
MediHelp rates the interaction as moderate. Captopril and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane cause vasodilation and myocardial depression, and ACE inhibitors blunt compensatory angiotensin II vasoconstriction. Together they can produce pronounced hypotension during induction and maintenance of anesthesia.
How serious is the interaction between Captopril and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during anesthesia and treat hypotension with fluids or vasopressors. Consider whether to withhold the ACE inhibitor on the morning of surgery according to local perioperative protocol.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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