Drug interactions
Captopril + Dexmedetomidine
Severity: Moderate
Captopril and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine lowers blood pressure and heart rate through central sympatholysis, and this adds to the effect of captopril. Hypotension and bradycardia may be more pronounced in volume-depleted or perioperative patients.
What this interaction means in plain words
Captopril and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-2 agonist sympatholysis and ACE inhibition.
What to do
Monitor blood pressure and heart rate continuously during dexmedetomidine infusion. Adjust the infusion rate and treat hypotension with fluids or vasopressors as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Captopril with Dexmedetomidine?
MediHelp rates the interaction as moderate. Captopril and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine lowers blood pressure and heart rate through central sympatholysis, and this adds to the effect of captopril. Hypotension and bradycardia may be more pronounced in volume-depleted or perioperative patients.
How serious is the interaction between Captopril and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during dexmedetomidine infusion. Adjust the infusion rate and treat hypotension with fluids or vasopressors as needed.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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