Drug interactions
Captopril + Ethacrynic acid
Severity: Moderate
Captopril and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid cause volume depletion, so adding captopril can lead to abrupt hypotension and acute renal insufficiency, especially at initiation. Electrolyte disturbances may also occur.
What this interaction means in plain words
Captopril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive effects of diuretic-induced volume depletion and ACE inhibitor reduction of efferent arteriolar tone.
What to do
Start captopril at a low dose, consider reducing the diuretic beforehand, and monitor blood pressure, creatinine and potassium within the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Captopril with Ethacrynic acid?
MediHelp rates the interaction as moderate. Captopril and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid cause volume depletion, so adding captopril can lead to abrupt hypotension and acute renal insufficiency, especially at initiation. Electrolyte disturbances may also occur.
How serious is the interaction between Captopril and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start captopril at a low dose, consider reducing the diuretic beforehand, and monitor blood pressure, creatinine and potassium within the first weeks.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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