Drug interactions
Captopril + Fluphenazine
Severity: Minor
Captopril and Fluphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has alpha-adrenergic blocking activity that can lower blood pressure and cause orthostatic hypotension. When combined with captopril, the blood pressure lowering may be additive, particularly in elderly patients or at treatment initiation.
What this interaction means in plain words
Captopril and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from alpha-1 adrenergic blockade by the phenothiazine and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Captopril with Fluphenazine?
MediHelp rates the interaction as minor. Captopril and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluphenazine has alpha-adrenergic blocking activity that can lower blood pressure and cause orthostatic hypotension. When combined with captopril, the blood pressure lowering may be additive, particularly in elderly patients or at treatment initiation.
How serious is the interaction between Captopril and Fluphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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