Drug interactions
Captopril + Liraglutide
Severity: Minor
Captopril and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may improve insulin sensitivity, so adding captopril to a patient on liraglutide can modestly increase glucose lowering. Hypoglycemia is uncommon with liraglutide alone but becomes more likely if a sulfonylurea or insulin is also used.
What this interaction means in plain words
Captopril and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Additive glucose-lowering through ACE inhibitor-related improvement in insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose after starting or changing captopril, especially in the first weeks. Consider reducing the dose of any concurrent insulin or sulfonylurea if glucose falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Captopril with Liraglutide?
MediHelp rates the interaction as minor. Captopril and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. ACE inhibitors may improve insulin sensitivity, so adding captopril to a patient on liraglutide can modestly increase glucose lowering. Hypoglycemia is uncommon with liraglutide alone but becomes more likely if a sulfonylurea or insulin is also used.
How serious is the interaction between Captopril and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing captopril, especially in the first weeks. Consider reducing the dose of any concurrent insulin or sulfonylurea if glucose falls.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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