Drug interactions
Insulin degludec-liraglutide + Liraglutide
Severity: Major
Insulin degludec-liraglutide and Liraglutide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The fixed-dose product already contains liraglutide, so adding separate liraglutide duplicates therapy and increases exposure. This raises the risk of gastrointestinal adverse effects, hypoglycemia and other GLP-1 related toxicity.
What this interaction means in plain words
Insulin degludec-liraglutide and Liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-liraglutide belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Therapeutic duplication of GLP-1 receptor agonism leading to excess pharmacological effect.
What to do
Do not use liraglutide together with the combination product; use only one liraglutide-containing regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Liraglutide
- Insulin glargine-lixisenatide + Liraglutide Major
- Alogliptin-metformin + Liraglutide Moderate
- Alogliptin-pioglitazone + Liraglutide Moderate
- Asenapine + Liraglutide Moderate
- Betamethasone + Liraglutide Moderate
- Chlorothiazide + Liraglutide Moderate
Frequently asked questions
Can I take Insulin degludec-liraglutide with Liraglutide?
MediHelp rates the interaction as major. Insulin degludec-liraglutide and Liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The fixed-dose product already contains liraglutide, so adding separate liraglutide duplicates therapy and increases exposure. This raises the risk of gastrointestinal adverse effects, hypoglycemia and other GLP-1 related toxicity.
How serious is the interaction between Insulin degludec-liraglutide and Liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use liraglutide together with the combination product; use only one liraglutide-containing regimen.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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