Drug interactions
Asenapine + Liraglutide
Severity: Moderate
Asenapine and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Asenapine can worsen glucose tolerance and weight, which may counteract the glycemic benefit of liraglutide. Diabetes control may need reassessment after the antipsychotic is started.
What this interaction means in plain words
Asenapine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Liraglutide belongs to Endocrine.
Why it happens
Antipsychotic-associated insulin resistance and metabolic effects oppose GLP-1 agonist glucose lowering; the exact mechanism is not fully established.
What to do
Monitor glucose, HbA1c and weight regularly after starting asenapine. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Liraglutide
Frequently asked questions
Can I take Asenapine with Liraglutide?
MediHelp rates the interaction as moderate. Asenapine and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Asenapine can worsen glucose tolerance and weight, which may counteract the glycemic benefit of liraglutide. Diabetes control may need reassessment after the antipsychotic is started.
How serious is the interaction between Asenapine and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, HbA1c and weight regularly after starting asenapine. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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