Drug interactions
Insulin glargine-lixisenatide + Liraglutide
Severity: Major
Insulin glargine-lixisenatide and Liraglutide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both liraglutide and lixisenatide are GLP-1 receptor agonists, so combining them duplicates therapy and increases gastrointestinal adverse effects and hypoglycemia risk. There is no established benefit from using two together.
What this interaction means in plain words
Insulin glargine-lixisenatide and Liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin glargine-lixisenatide belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Therapeutic duplication of GLP-1 receptor agonism with additive effects alongside insulin.
What to do
Avoid concurrent use of two GLP-1 receptor agonists and choose a single agent. If one must be switched, stop the other first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Liraglutide
- Insulin degludec-liraglutide + Liraglutide Major
- Alogliptin-metformin + Liraglutide Moderate
- Alogliptin-pioglitazone + Liraglutide Moderate
- Asenapine + Liraglutide Moderate
- Betamethasone + Liraglutide Moderate
- Chlorothiazide + Liraglutide Moderate
Frequently asked questions
Can I take Insulin glargine-lixisenatide with Liraglutide?
MediHelp rates the interaction as major. Insulin glargine-lixisenatide and Liraglutide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both liraglutide and lixisenatide are GLP-1 receptor agonists, so combining them duplicates therapy and increases gastrointestinal adverse effects and hypoglycemia risk. There is no established benefit from using two together.
How serious is the interaction between Insulin glargine-lixisenatide and Liraglutide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two GLP-1 receptor agonists and choose a single agent. If one must be switched, stop the other first.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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