Drug interactions
Captopril + Lornoxicam
Severity: Moderate
Captopril and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as lornoxicam can reduce the antihypertensive effect of ACE inhibitors. In patients with volume depletion, heart failure, or renal impairment, the combination also raises the risk of acute kidney injury and hyperkalemia.
What this interaction means in plain words
Captopril and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces renal perfusion, opposing ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium, especially in older or dehydrated patients. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Captopril with Lornoxicam?
MediHelp rates the interaction as moderate. Captopril and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as lornoxicam can reduce the antihypertensive effect of ACE inhibitors. In patients with volume depletion, heart failure, or renal impairment, the combination also raises the risk of acute kidney injury and hyperkalemia.
How serious is the interaction between Captopril and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, especially in older or dehydrated patients. Use the lowest effective NSAID dose for the shortest time or choose an alternative analgesic.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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