Drug interactions
Captopril + Nitroglycerin
Severity: Moderate
Captopril and Nitroglycerin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure by different mechanisms, so combined use can cause additive hypotension, particularly orthostatic hypotension. The combination is often used intentionally, for example in heart failure or angina with hypertension.
What this interaction means in plain words
Captopril and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Nitroglycerin belongs to Cardiovascular.
Why it happens
Additive vasodilation from nitrate-mediated venodilation and ACE inhibition-mediated reduction of angiotensin II.
What to do
Monitor blood pressure, especially after initiation or dose increases, and counsel patients about dizziness on standing; reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nitroglycerin
- Avanafil + Nitroglycerin Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Nitroglycerin + Sildenafil Contraindicated
- Nitroglycerin + Tadalafil Contraindicated
- Nitroglycerin + Vardenafil Contraindicated
- Dihydroergotamine intranasal + Nitroglycerin Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Nitroglycerin?
MediHelp rates the interaction as moderate. Captopril and Nitroglycerin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure by different mechanisms, so combined use can cause additive hypotension, particularly orthostatic hypotension. The combination is often used intentionally, for example in heart failure or angina with hypertension.
How serious is the interaction between Captopril and Nitroglycerin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially after initiation or dose increases, and counsel patients about dizziness on standing; reduce doses if symptomatic hypotension occurs.
What other medicines interact with Nitroglycerin?
MediHelp also lists interactions of Nitroglycerin with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Nitroglycerin page.
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