Drug interactions
Captopril + Phentermine
Severity: Moderate
Captopril and Phentermine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic that can increase blood pressure and heart rate, potentially reducing the antihypertensive effectiveness of captopril.
What this interaction means in plain words
Captopril and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Phentermine belongs to Central Nervous System.
Why it happens
Sympathomimetic pressor effects oppose ACE inhibitor blood pressure lowering.
What to do
Monitor blood pressure regularly and adjust antihypertensive therapy if control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Captopril with Phentermine?
MediHelp rates the interaction as moderate. Captopril and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine is a sympathomimetic that can increase blood pressure and heart rate, potentially reducing the antihypertensive effectiveness of captopril.
How serious is the interaction between Captopril and Phentermine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure regularly and adjust antihypertensive therapy if control is lost.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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