Drug interactions
Linezolid + Phentermine
Severity: Contraindicated
Linezolid and Phentermine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine releases norepinephrine and MAO inhibition by linezolid can amplify this effect, causing hypertensive crisis.
What this interaction means in plain words
Linezolid and Phentermine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Linezolid belongs to Anti Bacterial; Phentermine belongs to Central Nervous System.
Why it happens
MAO inhibition potentiates sympathomimetic catecholamine release.
What to do
Do not combine. Withhold phentermine during linezolid therapy and monitor blood pressure if exposure occurred.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
- Phentermine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Linezolid with Phentermine?
MediHelp rates the interaction as contraindicated. Linezolid and Phentermine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phentermine releases norepinephrine and MAO inhibition by linezolid can amplify this effect, causing hypertensive crisis.
How serious is the interaction between Linezolid and Phentermine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Withhold phentermine during linezolid therapy and monitor blood pressure if exposure occurred.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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