Drug interactions
Phentermine + Procarbazine
Severity: Contraindicated
Phentermine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic amine that releases noradrenaline, and procarbazine inhibits MAO. Together they may cause a hypertensive crisis.
What this interaction means in plain words
Phentermine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phentermine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition potentiates noradrenaline release from nerve terminals caused by phentermine.
What to do
Avoid the combination. Do not start phentermine within 14 days of stopping procarbazine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
- Phentermine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Phentermine with Procarbazine?
MediHelp rates the interaction as contraindicated. Phentermine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phentermine is a sympathomimetic amine that releases noradrenaline, and procarbazine inhibits MAO. Together they may cause a hypertensive crisis.
How serious is the interaction between Phentermine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Do not start phentermine within 14 days of stopping procarbazine.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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