Drug interactions
Phentermine + Rasagiline
Severity: Contraindicated
Phentermine and Rasagiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic amine whose labeling contraindicates use with or shortly after MAO inhibitors. Co-use risks hypertensive crisis and cardiovascular events.
What this interaction means in plain words
Phentermine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phentermine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Reduced catecholamine metabolism from MAO inhibition combined with phentermine-induced norepinephrine release causes exaggerated pressor effects.
What to do
Avoid the combination and do not start phentermine within 14 days of stopping rasagiline. Select an alternative weight-loss agent.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Phentermine and Rasagiline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Selegiline Contraindicated
- Phentermine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Phentermine with Rasagiline?
MediHelp rates the interaction as contraindicated. Phentermine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phentermine is a sympathomimetic amine whose labeling contraindicates use with or shortly after MAO inhibitors. Co-use risks hypertensive crisis and cardiovascular events.
How serious is the interaction between Phentermine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and do not start phentermine within 14 days of stopping rasagiline. Select an alternative weight-loss agent.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
