Drug interactions
Captopril + Potassium iodide
Severity: Moderate
Captopril and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide provides a potassium load, which with ACE inhibitor-related aldosterone suppression can raise serum potassium. Risk is greater with renal impairment and prolonged use.
What this interaction means in plain words
Captopril and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Potassium iodide belongs to Endocrine.
Why it happens
ACE inhibition reduces aldosterone, decreasing renal potassium excretion, while potassium iodide adds exogenous potassium.
What to do
Monitor serum potassium during prolonged or repeated use, especially in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Captopril with Potassium iodide?
MediHelp rates the interaction as moderate. Captopril and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide provides a potassium load, which with ACE inhibitor-related aldosterone suppression can raise serum potassium. Risk is greater with renal impairment and prolonged use.
How serious is the interaction between Captopril and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during prolonged or repeated use, especially in patients with renal impairment.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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