Drug interactions
Amlodipine-perindopril + Potassium iodide
Severity: Moderate
Amlodipine-perindopril and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide contains potassium that may add to the hyperkalemic effect of an ACE inhibitor, particularly with prolonged or high-dose use. Short courses at typical doses usually carry limited risk but may matter in renal impairment.
What this interaction means in plain words
Amlodipine-perindopril and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Potassium iodide belongs to Endocrine.
Why it happens
ACE inhibition decreases aldosterone-driven potassium excretion, so the potassium in iodide salts accumulates.
What to do
Monitor serum potassium if potassium iodide is used for more than a brief period or in patients with kidney disease. Reassess the need for therapy if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-valsartan + Potassium iodide Moderate
Frequently asked questions
Can I take Amlodipine-perindopril with Potassium iodide?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide contains potassium that may add to the hyperkalemic effect of an ACE inhibitor, particularly with prolonged or high-dose use. Short courses at typical doses usually carry limited risk but may matter in renal impairment.
How serious is the interaction between Amlodipine-perindopril and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium if potassium iodide is used for more than a brief period or in patients with kidney disease. Reassess the need for therapy if hyperkalemia develops.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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