Drug interactions
Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide
Severity: Moderate
Amlodipine-hydrochlorothiazide-valsartan and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Potassium iodide supplies potassium that may add to the hyperkalemic effect of valsartan, particularly in renal impairment. Hydrochlorothiazide may partly offset this. Risk is greatest with prolonged or high-dose potassium iodide.
What this interaction means in plain words
Amlodipine-hydrochlorothiazide-valsartan and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Potassium iodide belongs to Endocrine.
Why it happens
Additive potassium load combined with ARB-induced aldosterone suppression.
What to do
Monitor serum potassium and renal function if potassium iodide is used for more than a short course. Reassess therapy if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Major
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Major
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
- Amlodipine-valsartan + Potassium iodide Moderate
Frequently asked questions
Can I take Amlodipine-hydrochlorothiazide-valsartan with Potassium iodide?
MediHelp rates the interaction as moderate. Amlodipine-hydrochlorothiazide-valsartan and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Potassium iodide supplies potassium that may add to the hyperkalemic effect of valsartan, particularly in renal impairment. Hydrochlorothiazide may partly offset this. Risk is greatest with prolonged or high-dose potassium iodide.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function if potassium iodide is used for more than a short course. Reassess therapy if hyperkalemia develops.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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