Drug interactions
Captopril + Ropivacaine
Severity: Moderate
Captopril and Ropivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ropivacaine, particularly with epidural or spinal use, can cause sympathetic blockade and hypotension, which may be more marked in patients on ACE inhibitors. Systemic absorption alone has little effect, but neuraxial block is the relevant situation.
What this interaction means in plain words
Captopril and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Ropivacaine belongs to Central Nervous System.
Why it happens
Additive hypotension from sympathetic blockade and ACE inhibition.
What to do
Monitor blood pressure closely during neuraxial or major regional blocks and treat hypotension with fluids or vasopressors. Consider the timing of captopril before major procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Ropivacaine
Frequently asked questions
Can I take Captopril with Ropivacaine?
MediHelp rates the interaction as moderate. Captopril and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ropivacaine, particularly with epidural or spinal use, can cause sympathetic blockade and hypotension, which may be more marked in patients on ACE inhibitors. Systemic absorption alone has little effect, but neuraxial block is the relevant situation.
How serious is the interaction between Captopril and Ropivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during neuraxial or major regional blocks and treat hypotension with fluids or vasopressors. Consider the timing of captopril before major procedures.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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