Drug interactions
Captopril-hydrochlorothiazide + Ropivacaine
Severity: Moderate
Captopril-hydrochlorothiazide and Ropivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regional anesthesia with ropivacaine, especially epidural or spinal, can cause sympathetic blockade and hypotension. Patients on ACE inhibitors and diuretics may have exaggerated drops in blood pressure.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ropivacaine belongs to Central Nervous System.
Why it happens
Additive hypotension from local anesthetic sympathetic blockade and renin-angiotensin inhibition with diuretic volume depletion.
What to do
Monitor blood pressure during neuraxial or major nerve block and correct volume depletion beforehand. Consider holding the ACE inhibitor before major surgery per local protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Amlodipine-benazepril + Ropivacaine Moderate
- Benazepril + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
- Ciprofloxacin + Ropivacaine Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Ropivacaine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regional anesthesia with ropivacaine, especially epidural or spinal, can cause sympathetic blockade and hypotension. Patients on ACE inhibitors and diuretics may have exaggerated drops in blood pressure.
How serious is the interaction between Captopril-hydrochlorothiazide and Ropivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during neuraxial or major nerve block and correct volume depletion beforehand. Consider holding the ACE inhibitor before major surgery per local protocol.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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