Drug interactions
Amlodipine-benazepril + Ropivacaine
Severity: Moderate
Amlodipine-benazepril and Ropivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ropivacaine, particularly when given epidurally or as a spinal or regional block, can cause sympathetic blockade and hypotension. Antihypertensives, especially ACE inhibitors, can worsen this.
What this interaction means in plain words
Amlodipine-benazepril and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-benazepril belongs to Cardiovascular; Ropivacaine belongs to Central Nervous System.
Why it happens
Additive hypotension from local anesthetic sympathetic blockade and antihypertensive effects.
What to do
Monitor blood pressure during neuraxial or regional anesthesia, and manage hypotension with fluids or vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-benazepril
- Aliskiren + Amlodipine-benazepril Contraindicated
- Amlodipine-benazepril + Sacubitril / valsartan Contraindicated
- Aldesleukin + Amlodipine-benazepril Major
- Amifostine + Amlodipine-benazepril Major
- Amiloride + Amlodipine-benazepril Major
- Amlodipine-benazepril + Azilsartan Major
Other interactions of Ropivacaine
- Bupivacaine implant + Ropivacaine Major
- Bupivacaine liposome + Ropivacaine Major
- Benazepril + Ropivacaine Moderate
- Captopril-hydrochlorothiazide + Ropivacaine Moderate
- Captopril + Ropivacaine Moderate
- Ciprofloxacin + Ropivacaine Moderate
Frequently asked questions
Can I take Amlodipine-benazepril with Ropivacaine?
MediHelp rates the interaction as moderate. Amlodipine-benazepril and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ropivacaine, particularly when given epidurally or as a spinal or regional block, can cause sympathetic blockade and hypotension. Antihypertensives, especially ACE inhibitors, can worsen this.
How serious is the interaction between Amlodipine-benazepril and Ropivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during neuraxial or regional anesthesia, and manage hypotension with fluids or vasopressors.
What other medicines interact with Amlodipine-benazepril?
MediHelp also lists interactions of Amlodipine-benazepril with, for example, Aliskiren, Sacubitril / valsartan, Aldesleukin. The full list is on the Amlodipine-benazepril page.
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