Drug interactions
Benazepril + Ropivacaine
Severity: Moderate
Benazepril and Ropivacaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neuraxial or regional anesthesia with ropivacaine can cause sympathetic blockade and hypotension. ACE inhibitor therapy may amplify this and make hypotension harder to correct.
What this interaction means in plain words
Benazepril and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benazepril belongs to Cardiovascular; Ropivacaine belongs to Central Nervous System.
Why it happens
Additive hypotension from sympathetic blockade and suppression of angiotensin II-mediated vascular tone.
What to do
Monitor blood pressure closely during and after neuraxial block and have fluids and vasopressors ready. Follow local perioperative guidance on timing of ACE inhibitor doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benazepril
- Aliskiren + Benazepril Contraindicated
- Benazepril + Sacubitril / valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Amifostine + Benazepril Major
- Amiloride + Benazepril Major
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Major
Other interactions of Ropivacaine
Frequently asked questions
Can I take Benazepril with Ropivacaine?
MediHelp rates the interaction as moderate. Benazepril and Ropivacaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neuraxial or regional anesthesia with ropivacaine can cause sympathetic blockade and hypotension. ACE inhibitor therapy may amplify this and make hypotension harder to correct.
How serious is the interaction between Benazepril and Ropivacaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during and after neuraxial block and have fluids and vasopressors ready. Follow local perioperative guidance on timing of ACE inhibitor doses.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Benazepril page.
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