Drug interactions
Captopril + Saxagliptin
Severity: Moderate
Captopril and Saxagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and DPP-4 inhibitors reduce breakdown of substance P and bradykinin, so combining them may raise the risk of angioedema. Epidemiological data suggest a modest increase in risk.
What this interaction means in plain words
Captopril and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Saxagliptin belongs to Endocrine.
Why it happens
Reduced degradation of bradykinin and substance P through combined ACE and DPP-4 inhibition.
What to do
Counsel patients to report lip, tongue or facial swelling immediately. Stop one of the drugs if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Other interactions of Saxagliptin
- Albiglutide + Saxagliptin Moderate
- Amlodipine-benazepril + Saxagliptin Moderate
- Aripiprazole + Saxagliptin Moderate
- Asenapine + Saxagliptin Moderate
- Atazanavir + Saxagliptin Moderate
- Benazepril + Saxagliptin Moderate
Frequently asked questions
Can I take Captopril with Saxagliptin?
MediHelp rates the interaction as moderate. Captopril and Saxagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ACE inhibitors and DPP-4 inhibitors reduce breakdown of substance P and bradykinin, so combining them may raise the risk of angioedema. Epidemiological data suggest a modest increase in risk.
How serious is the interaction between Captopril and Saxagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report lip, tongue or facial swelling immediately. Stop one of the drugs if angioedema occurs.
What other medicines interact with Captopril?
MediHelp also lists interactions of Captopril with, for example, Aliskiren, Sacubitril / valsartan, Sacubitril-valsartan. The full list is on the Captopril page.
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