Drug interactions
Captopril + Torsemide
Severity: Moderate
Captopril and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to a loop diuretic can cause a marked fall in blood pressure, particularly after the first dose or when the patient is volume depleted. Renal function may also decline because glomerular filtration pressure falls.
What this interaction means in plain words
Captopril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril belongs to Cardiovascular; Torsemide belongs to Cardiovascular.
Why it happens
Diuretic-induced volume and sodium depletion activates the renin-angiotensin system, and ACE inhibition removes this compensation, producing additive hypotension and reduced glomerular filtration.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or titrating either drug, and consider lowering the diuretic dose before starting the ACE inhibitor in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Torsemide
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Captopril with Torsemide?
MediHelp rates the interaction as moderate. Captopril and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to a loop diuretic can cause a marked fall in blood pressure, particularly after the first dose or when the patient is volume depleted. Renal function may also decline because glomerular filtration pressure falls.
How serious is the interaction between Captopril and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or titrating either drug, and consider lowering the diuretic dose before starting the ACE inhibitor in volume-depleted patients.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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