Drug interactions
Captopril-hydrochlorothiazide + Chlorpropamide
Severity: Moderate
Captopril-hydrochlorothiazide and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas, increasing the chance of hypoglycemia. Conversely, thiazides can raise blood glucose and blunt sulfonylurea effect, so glycemic control may become unpredictable. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
ACE inhibitor enhancement of insulin sensitivity adds to sulfonylurea effect, while thiazide-induced hyperglycemia and potassium loss oppose it.
What to do
Monitor blood glucose closely when starting or stopping either agent and adjust the chlorpropamide dose as required. Counsel patients on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Chlorpropamide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can improve insulin sensitivity and may enhance the glucose-lowering effect of sulfonylureas, increasing the chance of hypoglycemia. Conversely, thiazides can raise blood glucose and blunt sulfonylurea effect, so glycemic control may become unpredictable. Chlorpropamide has a long half-life, so hypoglycemia may be prolonged.
How serious is the interaction between Captopril-hydrochlorothiazide and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping either agent and adjust the chlorpropamide dose as required. Counsel patients on hypoglycemia symptoms.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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