Drug interactions
Captopril-hydrochlorothiazide + Chlorthalidone
Severity: Moderate
Captopril-hydrochlorothiazide and Chlorthalidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two thiazide-type diuretics provides duplicate therapy, with additive diuresis, volume depletion, hypokalemia, hyponatremia and hypotension. The ACE inhibitor component adds to the blood pressure lowering and can worsen renal function in volume-depleted patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Chlorthalidone belongs to Cardiovascular.
Why it happens
Additive diuretic and electrolyte-wasting effects of two thiazide-type agents plus additive hypotensive effect of ACE inhibition.
What to do
Avoid therapeutic duplication unless deliberately used for resistant hypertension; if combined, monitor potassium, sodium, creatinine and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Chlorthalidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Chlorthalidone
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Chlorthalidone?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Chlorthalidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two thiazide-type diuretics provides duplicate therapy, with additive diuresis, volume depletion, hypokalemia, hyponatremia and hypotension. The ACE inhibitor component adds to the blood pressure lowering and can worsen renal function in volume-depleted patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Chlorthalidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid therapeutic duplication unless deliberately used for resistant hypertension; if combined, monitor potassium, sodium, creatinine and blood pressure.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
