Drug interactions
Captopril-hydrochlorothiazide + Clozapine
Severity: Moderate
Captopril-hydrochlorothiazide and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine frequently causes orthostatic hypotension, and combining it with an ACE inhibitor and a diuretic can intensify this, with risk of syncope and falls. Volume depletion from the diuretic worsens the problem.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Clozapine belongs to Central Nervous System.
Why it happens
Additive hypotension from clozapine alpha-adrenergic blockade and ACE inhibitor/diuretic effects.
What to do
Monitor blood pressure, especially during clozapine titration, and adjust antihypertensive doses as needed. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Clozapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Clozapine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine frequently causes orthostatic hypotension, and combining it with an ACE inhibitor and a diuretic can intensify this, with risk of syncope and falls. Volume depletion from the diuretic worsens the problem.
How serious is the interaction between Captopril-hydrochlorothiazide and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially during clozapine titration, and adjust antihypertensive doses as needed. Counsel patients to rise slowly.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
