Drug interactions
Captopril-hydrochlorothiazide + Cyclophosphamide
Severity: Moderate
Captopril-hydrochlorothiazide and Cyclophosphamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics have been reported to increase the myelosuppressive effects of cyclophosphamide, leading to deeper leukopenia. The clinical evidence is limited but the consequences could include infection.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Cyclophosphamide belongs to Oncology.
Why it happens
Proposed reduction in renal clearance of cyclophosphamide or its metabolites by thiazides; the mechanism is not firmly established.
What to do
Monitor complete blood counts closely, especially neutrophils, and adjust cyclophosphamide dosing per standard protocols. Consider a non-thiazide antihypertensive if myelosuppression is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Cyclophosphamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Cyclophosphamide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Cyclophosphamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics have been reported to increase the myelosuppressive effects of cyclophosphamide, leading to deeper leukopenia. The clinical evidence is limited but the consequences could include infection.
How serious is the interaction between Captopril-hydrochlorothiazide and Cyclophosphamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely, especially neutrophils, and adjust cyclophosphamide dosing per standard protocols. Consider a non-thiazide antihypertensive if myelosuppression is excessive.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
