Drug interactions
Captopril-hydrochlorothiazide + Deflazacort
Severity: Moderate
Captopril-hydrochlorothiazide and Deflazacort: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids such as deflazacort promote renal potassium loss, and combined with a thiazide the risk of hypokalemia is greater. Hypokalemia can lead to arrhythmias and muscle weakness. Corticosteroid fluid retention may also reduce antihypertensive effect.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Deflazacort belongs to Miscellaneous.
Why it happens
Additive renal potassium wasting from thiazide and glucocorticoid mineralocorticoid activity.
What to do
Monitor serum potassium and blood pressure, and supplement potassium if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Deflazacort?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Deflazacort can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids such as deflazacort promote renal potassium loss, and combined with a thiazide the risk of hypokalemia is greater. Hypokalemia can lead to arrhythmias and muscle weakness. Corticosteroid fluid retention may also reduce antihypertensive effect.
How serious is the interaction between Captopril-hydrochlorothiazide and Deflazacort?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and supplement potassium if required.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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