Drug interactions
Captopril-hydrochlorothiazide + Desvenlafaxine
Severity: Minor
Captopril-hydrochlorothiazide and Desvenlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, but captopril is not primarily cleared by CYP2D6, so no meaningful pharmacokinetic interaction is expected. Any effect on blood pressure is variable, as desvenlafaxine can raise blood pressure.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Desvenlafaxine belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; desvenlafaxine may modestly raise blood pressure, opposing antihypertensives.
What to do
No dose adjustment is needed; monitor blood pressure after starting or changing desvenlafaxine dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Desvenlafaxine?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Desvenlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is a weak CYP2D6 inhibitor, but captopril is not primarily cleared by CYP2D6, so no meaningful pharmacokinetic interaction is expected. Any effect on blood pressure is variable, as desvenlafaxine can raise blood pressure.
How serious is the interaction between Captopril-hydrochlorothiazide and Desvenlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor blood pressure after starting or changing desvenlafaxine dose.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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