Drug interactions
Captopril-hydrochlorothiazide + Dobutamine
Severity: Moderate
Captopril-hydrochlorothiazide and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine can lower serum potassium through beta-2 mediated cellular uptake, adding to thiazide-induced potassium loss. The resulting hypokalemia may predispose to arrhythmias in patients receiving inotropes.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Dobutamine belongs to Cardiovascular.
Why it happens
Beta-adrenergic shift of potassium into cells combined with renal potassium wasting from the thiazide.
What to do
Monitor serum potassium during dobutamine infusion and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Dobutamine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine can lower serum potassium through beta-2 mediated cellular uptake, adding to thiazide-induced potassium loss. The resulting hypokalemia may predispose to arrhythmias in patients receiving inotropes.
How serious is the interaction between Captopril-hydrochlorothiazide and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during dobutamine infusion and replace potassium as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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