Drug interactions
Captopril-hydrochlorothiazide + Drospirenone
Severity: Moderate
Captopril-hydrochlorothiazide and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, an effect that adds to ACE inhibitor-induced potassium retention. The thiazide partly offsets this, but hyperkalemia remains possible, particularly in renal impairment.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium retention from aldosterone antagonism (drospirenone) and ACE inhibition, partly offset by thiazide kaliuresis.
What to do
Check serum potassium during the first cycle of use and periodically thereafter; consider an alternative contraceptive in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Drospirenone?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, an effect that adds to ACE inhibitor-induced potassium retention. The thiazide partly offsets this, but hyperkalemia remains possible, particularly in renal impairment.
How serious is the interaction between Captopril-hydrochlorothiazide and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of use and periodically thereafter; consider an alternative contraceptive in patients with renal impairment.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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