Drug interactions
Captopril-hydrochlorothiazide + Fludrocortisone
Severity: Moderate
Captopril-hydrochlorothiazide and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid activity that promotes potassium excretion, and hydrochlorothiazide also causes potassium loss. Together they can produce clinically relevant hypokalemia, and fludrocortisone also causes sodium retention that opposes the antihypertensive effect of the combination.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Fludrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting, with mineralocorticoid-mediated sodium and fluid retention opposing antihypertensive effects.
What to do
Monitor serum potassium and blood pressure regularly, and supplement potassium or adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Fludrocortisone?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has strong mineralocorticoid activity that promotes potassium excretion, and hydrochlorothiazide also causes potassium loss. Together they can produce clinically relevant hypokalemia, and fludrocortisone also causes sodium retention that opposes the antihypertensive effect of the combination.
How serious is the interaction between Captopril-hydrochlorothiazide and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure regularly, and supplement potassium or adjust doses as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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